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Text File  |  1996-01-30  |  2KB  |  32 lines
  1.        Document 0809
  2.  DOCN  M9610809
  3.  TI    The role of IL-12 in the induction of organ-specific autoimmune
  4.        diseases.
  5.  DT    9601
  6.  AU    Trembleau S; Germann T; Gately MK; Adorini L; Roche Milano Ricerche,
  7.        Italy.
  8.  SO    Immunol Today. 1995 Aug;16(8):383-6. Unique Identifier : AIDSLINE
  9.        MED/96002283
  10.  AB    The concept that T cells are subdivided into T helper 1 (Th1) and Th2
  11.        subsets was recently extended to suggest that Th1 cells contribute to
  12.        the pathogenesis of several organ-specific autoimmune diseases, whereas
  13.        Th2 cells inhibit disease development. Here, Sylvie Trembleau and
  14.        colleagues examine the role of interleukin 12 (IL-12), a key cytokine
  15.        guiding the development of Th1 cells, in the induction of autoimmune
  16.        diseases, and discuss potential immunointervention strategies based on
  17.        administration of IL-12 antagonists.
  18.  DE    Animal  Antibodies, Monoclonal/IMMUNOLOGY/PHARMACOLOGY/THERAPEUTIC USE
  19.        Arthritis/CHEMICALLY INDUCED/IMMUNOLOGY  Autoimmune Diseases/CHEMICALLY
  20.        INDUCED/DRUG THERAPY/*IMMUNOLOGY  Collagen/TOXICITY  Diabetes Mellitus,
  21.        Insulin-Dependent/CHEMICALLY INDUCED/  IMMUNOLOGY  Drug Design
  22.        Encephalomyelitis, Allergic/IMMUNOLOGY/THERAPY  Female
  23.        Immunosuppressive Agents/PHARMACOLOGY/THERAPEUTIC USE  Immunotherapy,
  24.        Adoptive  Interleukin-12/ANTAGONISTS & INHIB/*PHYSIOLOGY/TOXICITY  Mice
  25.        Mice, Inbred BALB C  Mice, Inbred NOD  Models, Immunological  Organ
  26.        Specificity/*IMMUNOLOGY  Th1 Cells/*IMMUNOLOGY  JOURNAL ARTICLE  REVIEW
  27.        REVIEW, TUTORIAL
  28.  
  29.        SOURCE: National Library of Medicine.  NOTICE: This material may be
  30.        protected by Copyright Law (Title 17, U.S.Code).
  31.  
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