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M9620020.TXT
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1996-02-26
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Document 0020
DOCN M9620020
TI Study of HTLV-I antibodies in CSF and serum of neurolathyrism patients
in Bangladesh.
DT 9602
AU Haque A; Khan JK; Wouters G; Hossain M; Lambein F; Department of
Neurology, Institute for Postgraduate Medicine and; Research, Dhaka,
Bangladesh.
SO Ann Soc Belg Med Trop. 1995 Jun;75(2):131-4. Unique Identifier :
AIDSLINE MED/96066538
AB Neurolathyrism is a form of human spastic paraparesis related to the
overconsumption of the legume Lathyrus sativus or grass pea (Khesari in
Bangladesh) containing the neurotoxin 3-N-oxalyl-2,3-diaminopropanoic
acid (beta-ODAP). The clinical symptoms of neurolathyrism are similar to
those of Tropical Spastic Paraparesis. In order to eliminate the
proposed causative agent of TSP (HTLV-I) as a potential cause of the
symptoms ascribed to neurolathyrism, a total of 444 diagnosed lathyrism
patients were screened for HTLV-I antibodies. 50 CSF and 394 serum
samples were collected from male (415) and female (29) patients. Only 4
serum samples were found sero-positive for HTLV-I. This agrees with the
assumption that overconsumption of beta-ODAP containing Lathyrus seeds,
and not HTLV infection, is the causative agent for neurolathyrism.
DE Adult Bangladesh/EPIDEMIOLOGY Female Human HTLV-I
Antibodies/*ANALYSIS/CEREBROSPINAL FLUID Lathyrism/CEREBROSPINAL
FLUID/EPIDEMIOLOGY/*IMMUNOLOGY Male Paraparesis, Tropical
Spastic/IMMUNOLOGY Sampling Studies Support, Non-U.S. Gov't JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).