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M9620021.TXT
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1996-02-26
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Document 0021
DOCN M9620021
TI Detection of Epstein-Barr virus DNA in anal scrapings from HIV-positive
homosexual men.
DT 9602
AU Naher H; Lenhard B; Wilms J; Nickel P; Department of Dermatology,
Ruprecht-Karls-University, Heidelberg,; Germany.
SO Arch Dermatol Res. 1995;287(6):608-11. Unique Identifier : AIDSLINE
MED/96066118
AB Epstein-Barr virus (EBV) can infect epithelial cells as well as B
lymphocytes. Infection of the male and female genital tracts has
recently been demonstrated, and it has been suggested that the virus may
be sexually transmissible. In our study we investigated whether EBV can
be found in the anal region of sexually active homosexual men. Anal
scrapings from HIV-positive homosexual men and a heterosexual control
population were investigated using the polymerase chain reaction (PCR)
to screen for EBV DNA. EBV DNA was detected in 8 of 27 anal samples
(29.6%) from the homosexual men and 3 of 34 samples (8.8%) from the
heterosexual men. Our study shows that, like the genital tract, the anal
region can harbour EBV subclinically. This finding suggests that the
anal region may be a reservoir for EBV and that sexual transmission of
this virus may be possible.
DE Anus/*VIROLOGY Base Sequence Biopsy DNA, Viral/*ANALYSIS
Epithelium/VIROLOGY Herpesviridae Infections/*TRANSMISSION/VIROLOGY
Herpesvirus 4, Human/*ISOLATION & PURIF Homosexuality, Male Human HIV
Seropositivity/*VIROLOGY Male Molecular Sequence Data Polymerase
Chain Reaction Tumor Virus Infections/*TRANSMISSION/VIROLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).