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1996-02-26
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Document 0034
DOCN M9620034
TI Implications of human T-lymphotropic virus type-I and type-II testing in
donors and patients.
DT 9602
AU Fischer HE; Lichtiger B; Glassman AB; Division of Laboratory Medicine,
University of Texas M. D.; Anderson Cancer Center, Houston 77030, USA.
SO Ann Clin Lab Sci. 1995 Sep-Oct;25(5):373-80. Unique Identifier :
AIDSLINE MED/96042726
AB The retroviruses known as Human T-Lymphotropic Virus Types I and II
(HTLV-I and -II) were recognized before the human immunodeficiency virus
(HIV-1). Associated diseases of HTLV-I infection, including a particular
kind of leukemia or the development of a specific demyelinating disease,
have also been observed. Screening of blood donors for antibodies to
HTLV was mandated in November of 1988. This paper examines the biology
of HTLV-I and HTLV-II and reviews the testing methods for HTLV-I/II.
Data from 39,908 blood donations of volunteer donors at The University
of Texas M. D. Anderson Cancer Center (UTMDACC), Division of Laboratory
Medicine, Section of Transfusion Medicine are presented. Initially
reactive specimens for HTLV antibodies were 158 (0.4 percent). Of these
0.26 percent or 105 of 39,908 were repeatedly reactive. Eight hundred
and sixty-seven cancer patients were also tested for HTLV antibodies.
Eight or 0.9 percent were repeatedly reactive for HTLV antibodies by
enzyme immunoassays (EIA), but only one could be confirmed as positive.
HTLV-I/II has a very low incidence in the ambulatory population. The
relationship of clinical sequelae and the rate of transmission of these
viruses remain unclear. A readily applicable confirmatory test is not
yet available. Even significant improvements in the sensitivity and
specificity of testing will present ongoing problems for identification
of true HTLV carriers. The clinical decision-making process related to
the meaning of these results continues to be difficult.
DE Adult Aged *Blood Donors Female Human HTLV-I Antibodies/*BLOOD
HTLV-II Antibodies/*BLOOD Male Middle Age Neoplasms/VIROLOGY
Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).