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1996-02-26
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Document 0057
DOCN M9620057
TI Risk factors for HIV-1 seroconversion among injection drug users: a
case-control study.
DT 9602
AU Chitwood DD; Griffin DK; Comerford M; Page JB; Trapido EJ; Lai S; McCoy
CB; Comprehensive Drug Research Center, University of Miami School of;
Medicine, FL 33136, USA.
SO Am J Public Health. 1995 Nov;85(11):1538-42. Unique Identifier :
AIDSLINE MED/96036584
AB OBJECTIVES. A nested case-control study was conducted in Miami, Fla, to
determine risk factors associated with human immunodeficiency virus type
1 (HIV-1) seroconversion among injection drug users. METHODS. The study
identified 21 incident cases of HIV-1 infection and 76 unmatched
controls from two longitudinal cohorts of injection drug users. One
cohort consisted of individuals who originally had been recruited from
treatment centers; a second cohort was recruited from the street.
Logistic regression analyses that adjusted for age, gender, and race
were performed. RESULTS. The final model determined that the primary
independent risk factor that best explained the risk for seroconversion
was sharing injection equipment in the year prior to conversion; a
marginal risk factor was presence of sexually transmitted disease during
this same period. CONCLUSIONS. Both an injection component and a sexual
component play a role in seroconversion among injection drug users,
although the injection component is much stronger.
DE Adult Age Factors Case-Control Studies Cohort Studies Female
Florida/EPIDEMIOLOGY Human HIV
Seropositivity/COMPLICATIONS/*EPIDEMIOLOGY Male *Needle Sharing
Questionnaires Risk Factors Sex Behavior Sex Factors Substance
Abuse, Intravenous/*COMPLICATIONS Support, U.S. Gov't, P.H.S. JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).