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1996-02-26
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Document 0058
DOCN M9620058
TI Reduced risk of hepatitis B and hepatitis C among injection drug users
in the Tacoma syringe exchange program [see comments]
DT 9602
AU Hagan H; Jarlais DC; Friedman SR; Purchase D; Alter MJ; Seattle-King
County Department of Public Health, Wash. 98104,; USA.
SO Am J Public Health. 1995 Nov;85(11):1531-7. Unique Identifier : AIDSLINE
MED/96036583
CM Comment in: Am J Public Health 1995 Nov;85(11):1490-1
AB OBJECTIVES. This case-control study examined the association between
syringe exchange use and hepatitis B and C in injection drug users.
METHODS. Case patients included 28 injection drug users with acute
hepatitis B and 20 with acute hepatitis C reported to the health
department in a sentinel hepatitis surveillance county; control subjects
were injection drug users with no markers of exposure to hepatitis B or
C (n = 38 and 26, respectively) attending health department services
during the same period. Data were abstracted from clinic records.
RESULTS. Seventy-five percent of case patients with hepatitis B and 26%
of control subjects had never used the exchange; similar proportions
were found for the hepatitis C case and control groups. After adjustment
for demographic characteristics and duration of injecting drugs, nonuse
of the exchange was associated with a sixfold greater risk of hepatitis
B (odds ratio [OR] = 5.5; 95% confidence interval [CI] = 1.5, 20.4) and
a sevenfold greater risk of hepatitis C (OR = 7.3; 95% CI = 1.6, 32.8).
CONCLUSIONS. The results suggest that use of the exchange led to a
significant reduction in hepatitis B and hepatitis C in the county and
may have also prevented a substantial proportion of human
immunodeficiency virus infections in injection drug users.
DE Acute Disease Adult Age Factors Case-Control Studies Female
Hepatitis B/*ETIOLOGY/*PREVENTION & CONTROL Hepatitis
C/*ETIOLOGY/*PREVENTION & CONTROL Human Male Needle-Exchange
Programs/STATISTICS & NUMER DATA/*UTILIZATION Risk Factors Sex Factors
Substance Abuse, Intravenous/*COMPLICATIONS Washington JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).