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M9620108.TXT
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1996-02-26
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Document 0108
DOCN M9620108
TI [Incidence and differential diagnosis of cholestasis in AIDS--a
retrospective analysis of 73 patients]
DT 9602
AU Klinker H; Joeres R; Richter E; Medizinische Klinik, Universitat
Wurzburg.
SO Z Gastroenterol. 1993 Feb;31 Suppl 2:126-8. Unique Identifier : AIDSLINE
MED/96029875
AB A significant cholestasis constellation (alk. phosphatase and GGT each
increased to twice as much as the norm) in 73 consecutive patients with
AIDS was found in the course of the disease in 29 patients (= 39.7%). In
most of the patients advanced immunodeficiency with an average of 2.5
AIDS-defining diseases already existed. In the predominant number of
cases it was intrahepatic cholestasis with only slight icterus.
Therapeutic measures such as medicamentous treatment or high-caloric
parenteral nutrition were causal in two thirds of the cases; in a
quarter of the cases opportunistic infections, above all disseminating
mycobacteriosis were found. One third of the patients had already
existing liver diseases. Liver biopsy frequently proved diagnostic and
should be performed more often in the case of unclear liver findings in
AIDS patients.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/DRUG THERAPY/ PATHOLOGY
Adult Aged Anti-Infective Agents/ADMINISTRATION & DOSAGE/ADVERSE
EFFECTS AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/
PATHOLOGY Cholestasis, Intrahepatic/CHEMICALLY
INDUCED/*DIAGNOSIS/PATHOLOGY Diagnosis, Differential English Abstract
Female Human Liver/PATHOLOGY Liver Function Tests Male Middle Age
Retrospective Studies JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).