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M9620115.TXT
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1996-02-26
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Document 0115
DOCN M9620115
TI HTLV-I from Iranian Mashhadi Jews in Israel is phylogenetically related
to that of Japan, India, and South America rather than to that of Africa
and Melanesia.
DT 9602
AU Yamashita M; Achiron A; Miura T; Takehisa J; Ido E; Igarashi T; Ibuki K;
Osame M; Sonoda S; Melamed E; et al; Laboratory of Pathogenic Virus,
Kyoto University, Japan.
SO Virus Genes. 1995;10(1):85-90. Unique Identifier : AIDSLINE
GENBANK/D38403
AB A new endemic focus of human T-lymphotropic virus type I (HTLV-I) was
recently reported among Mashhadi Jews, a group of immigrants from
northeastern Iran to Israel. We extracted DNAs from fresh peripheral
blood mononuclear cells (PBMCs) and/or gargle mouthwash from 10 HTLV-I
carriers, who consisted of members of one family, and HTLV-I-associated
myelopathy (HAM) and adult T-cell leukemia (ATL) patients. Long terminal
repeat (LTR) regions of proviral DNAs were sequenced and analyzed
phylogenetically. In a phylogenetic tree, all the Mashhadi HTLV-I
isolates belonged to subtype A, one of the three subtypes of the
cosmopolitan type of HTLV-I, and made a tight cluster distinct from the
other isolates of subtype A from Japan, India, the Caribbean Basin, and
South America. Although a few nucleotide substitutions were observed
among the clones sequenced, no characteristic sequence variation was
found in different disease manifestations, even in one family or
different sources of DNA preparation.
DE Adult Africa Aged Base Sequence Carrier State DNA, Viral Female
Human HTLV-I/*CLASSIFICATION/ISOLATION & PURIF HTLV-I
Infections/BLOOD/*VIROLOGY India Iran Israel Japan Jews Leukemia,
T-Cell/BLOOD/VIROLOGY Leukocytes, Mononuclear/VIROLOGY Male Melanesia
Middle Age Molecular Sequence Data Paraparesis, Tropical
Spastic/BLOOD/VIROLOGY Phylogeny South America JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).