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1996-02-26
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Document 0159
DOCN M9620159
TI Hyponatremia in pediatric patients with HIV-1 infection.
DT 9602
AU Tolaymat A; al-Mousily F; Sleasman J; Paryani S; Neiberger R; Department
of Pediatrics, University of Florida College of; Medicine, Jacksonville,
USA.
SO South Med J. 1995 Oct;88(10):1039-42. Unique Identifier : AIDSLINE
MED/96011782
AB Hyponatremia has been recognized as a complication in adults with
acquired immunodeficiency syndrome (AIDS). We did a retrospective study
evaluating the medical records of 86 children (age 4 months to 21 years)
with human immunodeficiency virus (HIV-1) infection to determine the
frequency and clinical associations of hyponatremia. Twenty-two children
(26%) developed hyponatremia (serum sodium < 135 mEq/L; range 104 to 134
mEq/L; mean 130 mEq/L). Fourteen were male; 18 of the 22 patients were
black and 4 were white. At the time of hyponatremia, the children
frequently had comorbid associations, including 8 (35%) with AIDS
encephalopathy; 3 (14%) with cardiomyopathy; 3 (14%) using diuretics; 1
(5%) using pentamidine; 3 (14%) with bacterial pneumonia; 2 (9%)
requiring gastric lavage feedings; 2 (9%) with tuberculosis meningitis;
2 (9%) with gastroenteritis; 1 (5%) with infection caused by
Mycobacterium avium-intracellulare; 1 (5%) each with brain tumor and
tumor metastasis to brain. The cause of hyponatremia was attributed to
syndrome of inappropriate antidiuretic hormone in 8 children; poor
sodium intake and/or excessive diarrheal losses in 5; and the use of
diuretics in 3 patients. Mild hyponatremia with no identifiable cause
was found in 5 patients.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY
Adolescence Adult AIDS Dementia Complex/EPIDEMIOLOGY AIDS-Related
Complex/*COMPLICATIONS/IMMUNOLOGY Brain Neoplasms/EPIDEMIOLOGY
Cerebral Embolism and Thrombosis/EPIDEMIOLOGY Child Child, Preschool
Comorbidity CD4 Lymphocyte Count Female Gastroenteritis/EPIDEMIOLOGY
Human Hyponatremia/*EPIDEMIOLOGY/ETIOLOGY *HIV-1 Incidence Infant
Male Myocardial Diseases/EPIDEMIOLOGY Pneumonia/EPIDEMIOLOGY
Retrospective Studies Tuberculosis, Meningeal/EPIDEMIOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).