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M9620180.TXT
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1996-02-26
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Document 0180
DOCN M9620180
TI Analysis of antral biopsy specimens for evidence of acquired
mucosa-associated lymphoid tissue in HIV1-seropositive and HIV1-negative
patients.
DT 9602
AU Eidt S; Schrappe M; Fischer R; Institute of Pathology, University of
Cologne, Germany.
SO Scand J Gastroenterol. 1995 Jul;30(7):635-9. Unique Identifier :
AIDSLINE MED/96063241
AB BACKGROUND: There is conflicting evidence concerning the prevalence of
Helicobacter pylori gastritis in HIV1-infected patients. Furthermore, a
possible influence of immunodeficiency on the acquisition of
mucosa-associated lymphoid tissue (MALT) in the antral mucosa remains to
be elucidated. METHODS: Seventy-seven consecutive HIV1-infected patients
(mean age, 40.2 years) were compared in a prospective study with 77
HIV1-negative age-matched patients, using immunohistochemical stainings.
RESULTS: In HIV1-infected patients the prevalence of H. pylori gastritis
was lower and the inflammatory reaction less pronounced than in
controls. Lymphoid follicles and intraepithelial B cells were
significantly more often detected in HIV1-negative patients.
CONCLUSIONS: Evidence of acquired MALT is only rarely found in
HIV1-infected patients. These findings might contribute to the
explanation of why low-grade gastric MALT lymphomas have not been
reported in HIV1-infected patients so far.
DE Adult Biopsy Female Gastric Mucosa/IMMUNOLOGY/MICROBIOLOGY/PATHOLOGY
Gastritis/IMMUNOLOGY/MICROBIOLOGY/*PATHOLOGY Helicobacter
pylori/*ISOLATION & PURIF Helicobacter Infections/IMMUNOLOGY/*PATHOLOGY
Human HIV Infections/IMMUNOLOGY/MICROBIOLOGY/PATHOLOGY HIV
Seronegativity/IMMUNOLOGY HIV
Seropositivity/IMMUNOLOGY/MICROBIOLOGY/*PATHOLOGY HIV-1 Lymphoma,
Mucosa-Associated Lymphoid Tissue/IMMUNOLOGY/ MICROBIOLOGY/*PATHOLOGY
Male Middle Age Prospective Studies Pyloric
Antrum/MICROBIOLOGY/*PATHOLOGY Serodiagnosis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).