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1996-02-26
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Document 0205
DOCN M9620205
TI [Acute pancreatitis in patients infected with the human immunodeficiency
virus]
DT 9602
AU Veny A; Romeu J; Raventos A; Lopez MP; Sirera G; Clotet B; Unidad de
SIDA. Servicio de Medicina Interna, Hospital; Universitario Germans
Trias i Pujol, Badalona, Barcelona.
SO Rev Clin Esp. 1995 Sep;195(9):614-9. Unique Identifier : AIDSLINE
MED/96079689
AB This study was designed to define the etiological spectrum of acute
pancreatitis in patients infected with HIV in our environment and to
evaluate the relevance of cytomegalovirus as etiological agent. A
retrospective analysis was first made of clinical, analytical,
radiological and pathological findings of patients infected with HIV
clinically diagnosed of acute pancreatitis (period 1984-1993). Then,
clinical records of patients with necropsy proven CMV pancreatic
involvement were retrospectively analyzed (period 1985-1992) to evaluate
whether they had been diagnosed of acute pancreatitis when alive. Nine
cases were diagnosed of acute pancreatitis. A presumptive etiology
(didanosine) was considered in seven cases and idiopathic in two. Five
patients died, two from causes directly related to acute pancreatitis.
Necropsy was performed in two cases. Mortality was associated with the
development of renal insufficiency or the appearance of three or more
complications (p = 0.039). With regard to the second phase of the study
CMV pancreatic involvement was demonstrated in 4 necropsies out of a
total of 22 with evidence of CMV infection in one or more organs. None
of these patients was diagnosed of acute pancreatitis when alive. Acute
pancreatitis is an uncommon entity in patients infected with HIV.
Presumptively, it could be attributed to didanosine therapy in most of
our cases. The mortality rate was high, particularly when renal failure
developed. In no case was CMV involved as etiologic agent when the
patient was alive, although necropsy showed that pancreas can be
subclinically involved in the context of a CMV disseminated infection.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/MORTALITY/ PATHOLOGY
Acute Disease Adult Autopsy AIDS-Related Opportunistic
Infections/COMPLICATIONS/DIAGNOSIS/ MORTALITY/PATHOLOGY
Cytomegalovirus Infections/COMPLICATIONS/DIAGNOSIS/MORTALITY/ PATHOLOGY
English Abstract Female Human HIV
Infections/*COMPLICATIONS/MORTALITY/PATHOLOGY *HIV-1 Male Middle Age
Pancreatitis/*DIAGNOSIS/ETIOLOGY/MORTALITY/PATHOLOGY Prognosis
Retrospective Studies Spain/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).