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- Document 0306
- DOCN M9620306
- TI Mucociliary clearance abnormalities in the HIV-infected patient: a
- precursor to acute sinusitis.
- DT 9602
- AU Milgrim LM; Rubin JS; Small CB; Department of Otolaryngology, Mount
- Sinai Medical Center, New; York, N.Y., USA.
- SO Laryngoscope. 1995 Nov;105(11):1202-8. Unique Identifier : AIDSLINE
- MED/96069679
- AB An increasing number of patients with human immunodeficiency virus (HIV)
- suffer from acute infectious sinusitis, and many suffer recurrent
- episodes at a higher rate than their non-HIV counterparts. This study
- investigates a mechanism underlying the increased incidence of
- sinusitis, that of prolonged mucociliary transport time (MTT). Nasal
- mucociliary clearance was examined in 30 HIV-infected patients and 30
- matched, non-HIV controls using a nasal saccharin transport test. MTTs
- for the study group and the controls were 11.9 +/- 5.9 minutes and 7.4
- +/- 3.7 minutes, respectively. This difference attained statistical
- significance (P < .05). Study group patients with a history of sinusitis
- had a mean MTT of 13.7 +/- 6.8 minutes. Those with complaints of new
- onset nasal obstruction since HIV conversion had a mean MTT of 13.5 +/-
- 6.8 minutes. Statistical significance (P < .05) was found comparing
- these times to controls, as well as to study patients without these
- symptoms. These data support an inherent delay of mucociliary clearance
- in HIV-infected patients which is chronic, possibly irreversible, and,
- in association with nasal obstruction, represents a major mechanism of
- both the high acute and recurrent sinusitis rate in this population. The
- cause of the mucociliary delay is still unclear and needs to be further
- investigated.
- DE Acute Disease Adult Cross-Sectional Studies Female Human HIV
- Infections/COMPLICATIONS/*PHYSIOPATHOLOGY Male Middle Age
- *Mucociliary Clearance Nasal Obstruction/ETIOLOGY Pilot Projects
- Sinusitis/*ETIOLOGY Support, U.S. Gov't, P.H.S. Time Factors JOURNAL
- ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-