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M9620306.TXT
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1996-02-26
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Document 0306
DOCN M9620306
TI Mucociliary clearance abnormalities in the HIV-infected patient: a
precursor to acute sinusitis.
DT 9602
AU Milgrim LM; Rubin JS; Small CB; Department of Otolaryngology, Mount
Sinai Medical Center, New; York, N.Y., USA.
SO Laryngoscope. 1995 Nov;105(11):1202-8. Unique Identifier : AIDSLINE
MED/96069679
AB An increasing number of patients with human immunodeficiency virus (HIV)
suffer from acute infectious sinusitis, and many suffer recurrent
episodes at a higher rate than their non-HIV counterparts. This study
investigates a mechanism underlying the increased incidence of
sinusitis, that of prolonged mucociliary transport time (MTT). Nasal
mucociliary clearance was examined in 30 HIV-infected patients and 30
matched, non-HIV controls using a nasal saccharin transport test. MTTs
for the study group and the controls were 11.9 +/- 5.9 minutes and 7.4
+/- 3.7 minutes, respectively. This difference attained statistical
significance (P < .05). Study group patients with a history of sinusitis
had a mean MTT of 13.7 +/- 6.8 minutes. Those with complaints of new
onset nasal obstruction since HIV conversion had a mean MTT of 13.5 +/-
6.8 minutes. Statistical significance (P < .05) was found comparing
these times to controls, as well as to study patients without these
symptoms. These data support an inherent delay of mucociliary clearance
in HIV-infected patients which is chronic, possibly irreversible, and,
in association with nasal obstruction, represents a major mechanism of
both the high acute and recurrent sinusitis rate in this population. The
cause of the mucociliary delay is still unclear and needs to be further
investigated.
DE Acute Disease Adult Cross-Sectional Studies Female Human HIV
Infections/COMPLICATIONS/*PHYSIOPATHOLOGY Male Middle Age
*Mucociliary Clearance Nasal Obstruction/ETIOLOGY Pilot Projects
Sinusitis/*ETIOLOGY Support, U.S. Gov't, P.H.S. Time Factors JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).