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M9620371.TXT
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1996-02-26
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Document 0371
DOCN M9620371
TI Pneumocystis carinii pneumonia during treatment for recurrent breast
cancer: a case report.
DT 9602
AU Koibuchi Y; Iino Y; Yokoe T; Oyama T; Nakajima T; Morishita Y; Second
Department of Surgery, Gunma University School of; Medicine, Maebashi.
SO Jpn J Clin Oncol. 1995 Oct;25(5):218-21. Unique Identifier : AIDSLINE
MED/96045582
AB We describe a case of Pneumocystis carinii pneumonia (PCP) in a woman
with recurrent breast cancer without human immunodeficiency virus (HIV)
infection. The PCP was associated with severe lymphocytopenia due to
treatment with anticancer agents in combination with granulocyte
colony-stimulating factor (G-CSF). Despite the severe lymphocytopenia,
the total leucocyte count never fell below 3000/mm3 during the
treatment. It was difficult to determine whether the patient's
respiratory failure was caused by severe infectious pneumonia,
hypersensitivity pneumonia or pneumonitis carcinomatosis. She was
treated with steroid for suspected drug-induced hypersensitivity
pneumonia. However, as her condition did not improve, PCP was suspected,
and sulfamethoxazole-trimethoprim was administered. At the same time,
anticancer drugs were administered to half the progression of the
cancer, since lymphangitis carcinomatosa was also suspected. The severe
respiratory failure did not improve, and the patient died on day 23
after admission. At autopsy, the cause of death was confirmed to
respiratory failure due to PCP.
DE Adult Bone Neoplasms/SECONDARY Breast Neoplasms/*COMPLICATIONS/THERAPY
Carcinoma, Infiltrating Duct/*COMPLICATIONS/SECONDARY/THERAPY Case
Report Fatal Outcome Female Human Liver Neoplasms/SECONDARY
Lymphopenia/ETIOLOGY Pneumonia, Pneumocystis
carinii/DIAGNOSIS/*ETIOLOGY Respiratory Insufficiency/ETIOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).