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1996-02-26
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Document 0486
DOCN M9620486
TI Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma.
DT 9602
AU de Lellis L; Fabris M; Cassai E; Corallini A; Giraldo G; Feo C; Monini
P; Institute of Microbiology, University of Ferrara, Italy.
SO J Infect Dis. 1995 Dec;172(6):1605-7. Unique Identifier : AIDSLINE
MED/96083512
AB The pathogenesis of Kaposi's sarcoma (KS) is suggested to be related to
an infectious agent transmitted by sexual contact. Recently, DNA
sequences homologous to gamma herpesviridae have been identified in
AIDS-associated KS, but no information is available concerning
non-AIDS-associated KS. Five classic, 12 endemic, and 17 AIDS-associated
KS skin lesion specimens were analyzed and all were positive for these
novel DNA sequences. Twenty-four specimens from normal skin were
negative. These novel sequences were also found in lymph nodes from
human immunodeficiency virus-positive patients with AIDS or
lymphadenopathy syndrome but not in peripheral blood mononuclear cells
from normal subjects. Therefore, the data support the view that a novel
gamma herpesvirus might be specifically associated with KS
etiopathogenesis.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS DNA, Viral/*ANALYSIS
Herpesviridae/*GENETICS Human Polymerase Chain Reaction Sarcoma,
Kaposi's/*VIROLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).