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M9620496.TXT
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1996-02-26
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Document 0496
DOCN M9620496
TI Excess intrauterine fetal demise associated with maternal human
immunodeficiency virus infection.
DT 9602
AU Langston C; Lewis DE; Hammill HA; Popek EJ; Kozinetz CA; Kline MW;
Hanson IC; Shearer WT; Department of Pathology, Baylor College of
Medicine, Houston, TX; 77030, USA.
SO J Infect Dis. 1995 Dec;172(6):1451-60. Unique Identifier : AIDSLINE
MED/96083487
AB A prospective study of transplacental transmission of human
immunodeficiency virus (HIV) showed an increased rate of spontaneous
fetal demise in HIV-seropositive mothers: 14 losses in 124 pregnancies.
HIV was detected in placental and fetal tissues in 7 of 14 by in situ
hybridization. The proportion of fetal infection far exceeded the
transmission rate of 13% in liveborn babies. No association was seen
between fetal transmission and a maternal history of drug abuse or
coinfections; mothers with AIDS more often had fetal loss associated
with HIV transmission than did asymptomatic mothers. In affected
fetuses, HIV was detected in many tissues and was associated with thymic
pathology. This suggests that maternal HIV infection increases the risk
for pregnancy loss associated with HIV transmission. The possibility
that HIV may be fetotoxic, that thymic dysfunction may interfere with
pregnancy progression, or that the intrauterine milieu in
HIV-seropositive pregnancies may be unfavorable (or a combination of
factors) should be considered.
DE Adolescence Adult Child Disease Transmission, Vertical Female Fetal
Death/*ETIOLOGY Human HIV Infections/*COMPLICATIONS Pregnancy
*Pregnancy Complications, Infectious Prospective Studies Support, U.S.
Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).