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M9620495.TXT
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1996-02-26
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Document 0495
DOCN M9620495
TI Human immunodeficiency virus type 1-infected cells in breast milk:
association with immunosuppression and vitamin A deficiency.
DT 9602
AU Nduati RW; John GC; Richardson BA; Overbaugh J; Welch M; Ndinya-Achola
J; Moses S; Holmes K; Onyango F; Kreiss JK; Department of Pediatrics,
University of Nairobi, Kenya.
SO J Infect Dis. 1995 Dec;172(6):1461-8. Unique Identifier : AIDSLINE
MED/96083488
AB Breast milk samples from human immunodeficiency virus type 1
(HIV-1)-seropositive women were analyzed by polymerase chain reaction to
determine the prevalence and determinants of HIV-1-infected cells in
breast milk. Breast milk samples (212) were collected from 107 women,
and 58% of the samples had detectable HIV-1 DNA. The proportion of
HIV-1-infected cells in the milk samples ranged from 1 to 3255/10(4)
cells. Breast milk samples with detectable HIV-1 DNA were more likely to
be from women with absolute CD4 cell counts of < 400 (odds ratio, 3.1;
95% confidence interval [CI], 1.5-7.0). Severe vitamin A deficiency (<
20 micrograms/dL) was associated with a 20-fold increased risk of having
HIV-1 DNA in breast milk among women with < 400 CD4 cells/mm3 (95% CI,
2.1-188.5). Women with CD4 cell depletion, especially those with vitamin
A deficiency, may be at increased risk of transmitting HIV-1 to their
infants through breast milk.
DE Adolescence Adult CD4 Lymphocyte Count *Disease Transmission,
Vertical Female Human HIV-1/*ISOLATION & PURIF *Immune Tolerance
Milk, Human/*VIROLOGY Pregnancy Support, U.S. Gov't, P.H.S. Vitamin A
Deficiency/*VIROLOGY CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED
CONTROLLED TRIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).