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1996-02-26
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Document 0501
DOCN M9620501
TI Quantitative measures of human immunodeficiency virus-specific
antibodies predict progression to AIDS.
DT 9602
AU Strathdee SA; Frank JW; McLaughlin J; Leblanc M; Major C; O'Shaughnessy
MV; Read SE; British Columbia Centre for Excellence in HIV/AIDS,
Vancouver,; Canada.
SO J Infect Dis. 1995 Nov;172(5):1375-9. Unique Identifier : AIDSLINE
MED/96036402
AB Studies examining specific antibodies directed against antigenic
components of human immunodeficiency virus (HIV), as potential markers
of progression to AIDS, have reported inconsistent results. We used
reflectance densitometry and survival analysis to determine whether
single quantitative measures of HIV-specific antibodies predicted
progression to AIDS in a prospective cohort of 159 HIV-infected
homosexual men. Lowered baseline levels of p24 antibody and p24/gp41
antibody ratio were independent predictors of progression to AIDS and
retained statistical significance after simultaneously controlling for
CD4:CD8 ratio, age, use of zidovudine, and clinical symptoms.
Quantitative measures of p24 antibody and p24/gp41 antibody ratio
warrant further study with regards to their clinical application as
markers of HIV disease progression.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PHYSIOPATHOLOGY Adult
Age Factors Analysis of Variance Bisexuality Comparative Study
CD4-CD8 Ratio Disease Progression Follow-Up Studies Homosexuality,
Male Human HIV Antibodies/*BLOOD HIV Core Protein p24/IMMUNOLOGY HIV
Envelope Protein gp41/IMMUNOLOGY HIV
Infections/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY HIV
Seropositivity/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY Male Multivariate
Analysis Predictive Value of Tests Prognosis Support, Non-U.S. Gov't
Time Factors Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).