home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Collection of Education
/
collectionofeducationcarat1997.iso
/
HEALTH
/
MED9602.ZIP
/
M9620584.TXT
< prev
next >
Wrap
Text File
|
1996-02-26
|
2KB
|
37 lines
Document 0584
DOCN M9620584
TI Effect of vitamin and trace element supplementation on immune indices in
healthy elderly.
DT 9602
AU Pike J; Chandra RK; Department of Pediatrics, Memorial University of
Newfoundland,; St. John's, Canada.
SO Int J Vitam Nutr Res. 1995;65(2):117-21. Unique Identifier : AIDSLINE
MED/96089946
AB Aging is associated with a progressive decline in the immune system and
a greater susceptibility to infection. This double-blind,
placebo-controlled study, examined the effect of a vitamin and trace
element supplement on immune responses of healthy, noninstitutionalized
elderly subjects. Forty-seven subjects aged 61-79 years were randomly
assigned to receive placebo or micronutrient supplementation for one
year. Thirty-five individuals completed the one-year study. Immune
function was assessed before and after the period of supplementation.
Cell-mediated immune function assessed by the number of T cells and
subsets remained constant in the supplemented group and there was a
significant increase in CD57 natural killer cells. In contrast, a
significant decrease in T cells, CD4 cells, and CD4: CD8 ratio was noted
in the placebo group. Supplementation with micronutrients can play a
crucial role in the maintenance of normal immune function in the
elderly.
DE Aged Aging/*IMMUNOLOGY Antigens, CD3/ANALYSIS Antigens, CD4/ANALYSIS
Antigens, CD57/ANALYSIS Antigens, CD8/ANALYSIS CD4-CD8 Ratio
Double-Blind Method Female Food, Fortified Human Immune System/*DRUG
EFFECTS/PHYSIOLOGY Killer Cells, Natural/IMMUNOLOGY/PHYSIOLOGY Male
Middle Age Support, Non-U.S. Gov't T-Lymphocytes/IMMUNOLOGY/PHYSIOLOGY
Trace Elements/ADMINISTRATION & DOSAGE/*PHARMACOLOGY
Vitamins/ADMINISTRATION & DOSAGE/*PHARMACOLOGY CLINICAL TRIAL JOURNAL
ARTICLE RANDOMIZED CONTROLLED TRIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).