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1996-02-26
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Document 0620
DOCN M9620620
TI [The role of T-lymphocyte subsets in susceptibility and resistance to
induction of autoimmunity in the central nervous system]
DT 9602
AU Mostarica-Stojkovic M; Vukmanovic S; Radojkovic M; Ramic Z; Vuckovic S;
Ejdus L; Pravica V; Simic MM; Lukic ML; Institute of Microbiology and
Immunology, School of Medicine,; University of Belgrade.
SO Glas Srp Akad Nauka [Med]. 1994;(44):35-43. Unique Identifier : AIDSLINE
MED/96021692
AB The importance of two major subsets of T cells (CD4 and CD8) for the
induction of EAE was analysed in two strains of rats differing in
susceptibility to EAE and the level of IL 2 production. It was found
that CD8 cells do not play a role in the induction or in the inherent
resistance to EAE. Additionally, the elimination of CD8 cells does not
increase the IL 2 production in lymphoid cell cultures. Based on these
and previous results showing that a low dose of cyclophosphamide readily
abrogates the resistance to EAE and enhances the IL 2 production. Thus
it was concluded that genetically determined differences in
susceptibility to EAE are governed by immunoregulatory genes whose
effect appears to be mediated at the level of cellular interaction of
different subsets of CD4 T cells.
DE Animal Central Nervous System/IMMUNOLOGY CD4-CD8 Ratio Disease
Susceptibility/IMMUNOLOGY Encephalomyelitis,
Allergic/*IMMUNOLOGY/PHYSIOPATHOLOGY English Abstract Immunity
Interleukin-2/BIOSYNTHESIS Lymphocyte Transformation Rats
T-Lymphocyte Subsets/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).