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1996-02-26
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Document 0636
DOCN M9620636
TI HIV-related non-Hodgkin's lymphoma among European AIDS patients. AIDS in
Europe Study Group. AIDS in Europe Study Group.
DT 9602
AU Pedersen C; Barton SE; Chiesi A; Skinhoj P; Katlama C; Johnson A; van
Lunzen J; Hirschel B; Maayan S; Lundgren JD; Department of Infectious
Disease, State University Hospital,; Copenhagen, Denmark.
SO Eur J Haematol. 1995 Oct;55(4):245-50. Unique Identifier : AIDSLINE
MED/96013862
AB The epidemiology of HIV associated non-Hodgkin's lymphoma (NHL) was
investigated in 6550 European patients with AIDS. NHL was diagnosed in
3.5% of all patients at the time of the AIDS diagnosis. Although the
probability of being diagnosed with NHL at AIDS diagnosis was
significantly higher among intravenous drug users than among homosexual
men, and was associated with increasing age, the observed incidences of
NHL were more strikingly similar than any differences. The rate of
developing NHL after a previous AIDS diagnosis was 2.4 per 100 patient
years of follow-up, and remained constant during a 5-year follow-up
period. While primary brain lymphomas comprised only 9% of NHL diagnosed
at the time of AIDS, they comprised 38% of NHL diagnosed after AIDS (p <
0.001). The prognosis for patients with NHL at AIDS diagnosis was poor
with a median survival of 5 months. A diagnosis of primary brain
lymphoma was uniformly associated with a poor outcome. It is concluded
that the probability of developing NHL in late stage HIV infection is
lower than previously anticipated from the results of small studies on
patients receiving long-term anti-retroviral therapy.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Adult Age Factors
Comparative Study Europe/EPIDEMIOLOGY Female Homosexuality, Male
Human *HIV HIV Infections/*EPIDEMIOLOGY Incidence Lymphoma,
AIDS-Related/*EPIDEMIOLOGY/MORTALITY Male Probability Sex
Characteristics Substance Abuse, Intravenous Survival Rate JOURNAL
ARTICLE MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).