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1996-02-26
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Document 0654
DOCN M9620654
TI Association between HIV and other DNA viruses in vitro.
DT 9602
AU Cisterna R; Campelo C; Gorrino T; Malave C; Sarria L; Lardelli P;
Fernandez de Aranguiz A; Madariaga L; Immunology, Microbiology and
Parasitology Department, University; of Basque Country, Bilbao, Spain.
SO Eur J Clin Microbiol Infect Dis. 1995 Jul;14(7):591-6. Unique Identifier
: AIDSLINE MED/96047084
AB To investigate the association of human immunodeficiency virus (HIV)
with various DNA viruses, including hepatitis B virus (HBV),
cytomegalovirus (CMV) and Epstein-Barr virus, (EBV), simultaneous
detection of HIV p24 antigen, HBV surface antigen and DNA, CMV-DNA and
EBV-DNA expression was performed in phytohemagglutinin-stimulated
peripheral blood mononuclear (PBMC) culture supernatants obtained from
54 individuals at risk for HIV infection. HIV expression in PBMC culture
supernatants never occurred alone; expression of other viruses was
always detected in the 24 samples expressing HIV antigen in vitro.
Furthermore, in 16 patients expression of other viruses was detected
without HIV expression, and in 14 patients none of the tested viruses
were detected. These results indicate a strong association between the
presence of HIV antibody and expression of DNA viruses in vitro (p =
0.0001). The coexpression of these viruses could be related to the
evolution of HIV infection and AIDS.
DE Cells, Cultured Cytomegalovirus/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF
DNA, Viral/ANALYSIS Hepatitis B Virus/GENETICS/IMMUNOLOGY/*ISOLATION &
PURIF Herpesvirus 4, Human/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF
Human HIV Core Protein p24/ANALYSIS HIV Infections/*VIROLOGY
Leukocytes, Mononuclear/VIROLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).