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1996-02-26
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Document 0659
DOCN M9620659
TI Role of antigenemia assay in the early diagnosis and prediction of human
cytomegalovirus organ involvement in AIDS patients.
DT 9602
AU Francisci D; Tosti A; Preziosi R; Baldelli F; Stagni G; Pauluzzi S;
Institute of Infectious Diseases, University of Perugia,; Policlinico
Monteluce, Italy.
SO Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):498-503. Unique
Identifier : AIDSLINE MED/96082793
AB The role of an antigenemia assay in the diagnosis and prediction of
human cytomegalovirus (HCMV) disease in AIDS patients was evaluated. The
clinical history of 62 patients with advanced HIV infection from whom a
total of 248 blood samples were drawn and tested by the HCMV antigenemia
assay was examined retrospectively. Between December 1992 and January
1994, 28 episodes of HCMV disease with organ involvement were recorded;
the antigenemia assay was positive in 23 of them (82.1%). In particular,
this test was positive in 11 of 12 (91.6%) first episodes and in 3 of 3
(100%) recurrent episodes occurring in patients not receiving
maintenance therapy. The same test was positive in 9 of 13 (69.2%)
recurrent episodes occurring in patients receiving maintenance therapy.
The first occurrence of HCMV disease was always preceded by a positive
antigenemia assay 2 and 4 months before diagnosis (in all 7 patients of
the 7 for whom a blood sample was available before HCMV disease). A
positive antigenemia test result was not always followed by organ
involvement, but a high positive cell count (> 100/200,000
polymorphonuclear leukocytes) strongly correlated with the appearance of
HCMV disease in the following 1 to 3 months (100% of cases). The
antigenemia assay is a useful and reliable indirect method for the
diagnosis and prediction of HCMV end-organ disease in severely and
persistently immunocompromised AIDS patients.
DE Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS Adolescence
Adult Aged Antigens, Viral/*BLOOD AIDS-Related Opportunistic
Infections/BLOOD/COMPLICATIONS/ *DIAGNOSIS Child Child, Preschool
Cytomegalovirus/ISOLATION & PURIF Cytomegalovirus
Infections/BLOOD/COMPLICATIONS/*DIAGNOSIS Female Fluorescent Antibody
Technique, Indirect Human Linear Models Male Middle Age Predictive
Value of Tests Retrospective Studies Serodiagnosis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).