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- Document 0659
- DOCN M9620659
- TI Role of antigenemia assay in the early diagnosis and prediction of human
- cytomegalovirus organ involvement in AIDS patients.
- DT 9602
- AU Francisci D; Tosti A; Preziosi R; Baldelli F; Stagni G; Pauluzzi S;
- Institute of Infectious Diseases, University of Perugia,; Policlinico
- Monteluce, Italy.
- SO Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):498-503. Unique
- Identifier : AIDSLINE MED/96082793
- AB The role of an antigenemia assay in the diagnosis and prediction of
- human cytomegalovirus (HCMV) disease in AIDS patients was evaluated. The
- clinical history of 62 patients with advanced HIV infection from whom a
- total of 248 blood samples were drawn and tested by the HCMV antigenemia
- assay was examined retrospectively. Between December 1992 and January
- 1994, 28 episodes of HCMV disease with organ involvement were recorded;
- the antigenemia assay was positive in 23 of them (82.1%). In particular,
- this test was positive in 11 of 12 (91.6%) first episodes and in 3 of 3
- (100%) recurrent episodes occurring in patients not receiving
- maintenance therapy. The same test was positive in 9 of 13 (69.2%)
- recurrent episodes occurring in patients receiving maintenance therapy.
- The first occurrence of HCMV disease was always preceded by a positive
- antigenemia assay 2 and 4 months before diagnosis (in all 7 patients of
- the 7 for whom a blood sample was available before HCMV disease). A
- positive antigenemia test result was not always followed by organ
- involvement, but a high positive cell count (> 100/200,000
- polymorphonuclear leukocytes) strongly correlated with the appearance of
- HCMV disease in the following 1 to 3 months (100% of cases). The
- antigenemia assay is a useful and reliable indirect method for the
- diagnosis and prediction of HCMV end-organ disease in severely and
- persistently immunocompromised AIDS patients.
- DE Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS Adolescence
- Adult Aged Antigens, Viral/*BLOOD AIDS-Related Opportunistic
- Infections/BLOOD/COMPLICATIONS/ *DIAGNOSIS Child Child, Preschool
- Cytomegalovirus/ISOLATION & PURIF Cytomegalovirus
- Infections/BLOOD/COMPLICATIONS/*DIAGNOSIS Female Fluorescent Antibody
- Technique, Indirect Human Linear Models Male Middle Age Predictive
- Value of Tests Retrospective Studies Serodiagnosis JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-