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1996-02-26
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Document 0808
DOCN M9620808
TI Interleukin-10 and its receptor.
DT 9602
AU Ho AS; Moore KW; Department of Immunology, DNAX Research Institute of
Molecular; and Cellular Biology, Palo Alto, CA 94306, USA.
SO Ther Immunol. 1994 Jun;1(3):173-85. Unique Identifier : AIDSLINE
MED/96053301
AB The cytokine interleukin-10 (IL-10) has several important activities on
cells of the immune system. IL-10 profoundly suppresses activation of
macrophages, inhibiting their ability to secrete cytokines and serve as
accessory cells for stimulation of T cell and natural killer (NK) cell
function. IL-10 also plays a role in stimulating proliferation and
differentiation of B cells, mast cells, and both mature and immature T
cells. At least two herpesviruses harbor analogs of the IL-10 gene; the
Epstein-Barr virus (EBV) homolog (BCRF1, viral IL-10, vIL-10) shares
several of the cellular cytokine's activities, one or all of which may
be important in the host-virus relationship. This article reviews recent
studies on the function of IL-10 and discusses the initial
characterization of its receptor.
DE Animal Antigen-Presenting Cells/IMMUNOLOGY Autoimmunity/IMMUNOLOGY
B-Lymphocytes/CYTOLOGY Cell Differentiation Genes, Structural Genes,
Structural, Viral Hematopoiesis Herpesvirus 4, Human/GROWTH &
DEVELOPMENT Human Immune Tolerance Inflammation/IMMUNOLOGY
Interleukin-10/*PHYSIOLOGY Lymphocyte Transformation Macrophage
Activation Macrophages/IMMUNOLOGY Receptors, Interleukin/*PHYSIOLOGY
T-Lymphocytes/IMMUNOLOGY Th1 Cells/IMMUNOLOGY Th2 Cells/IMMUNOLOGY
JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).