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1996-02-26
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Document 0868
DOCN M9620868
TI Clinical isolates of Mycobacterium simiae in San Antonio, Texas. An
11-yr review.
DT 9602
AU Valero G; Peters J; Jorgensen JH; Graybill JR; Department of Infectious
Diseases, University of Texas Health; Science Center at San Antonio
78284-7870, USA.
SO Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1555-7. Unique
Identifier : AIDSLINE MED/96048813
AB During a period of 11 yr (1983-1993) 137 clinical isolates of
Mycobacterium simiae obtained from 75 patients were identified in a
University hospital in San Antonio, Texas. One hundred twenty-eight
isolates (93%) were from a pulmonary source, four (3%) from blood, and
five from other sites including skin, urine, lymph node, bone marrow,
and brain. Of 62 evaluable patients, six (10%) had definite infection,
nine (14%) had probable disease, and 48 (76%) were thought to be
colonized. During the last 2 yr of the study (1992 and 1993), M. simiae
became the second most frequently isolated nontuberculous mycobacterium
at this institution surpassed only by Mycobacterium avium complex. There
are limited data about effective treatment for this multidrug-resistant
organism. New macrolides, quinolones, ethambutol, clofazimine, and
aminoglycosides are promising therapeutic agents.
DE Adult AIDS-Related Opportunistic Infections/MICROBIOLOGY Child,
Preschool Drug Resistance, Microbial Drug Resistance, Multiple Female
Human HIV-1 Male Microbial Sensitivity Tests Middle Age
Mycobacterium/DRUG EFFECTS/*ISOLATION & PURIF Mycobacterium
Infections/MICROBIOLOGY Retrospective Studies Texas JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).