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1996-02-26
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Document 0876
DOCN M9620876
TI T cell-rich B cell lymphoma bearing Epstein-Barr virus in tumor cells: a
case of IBL-T-like lesion following Lennert's lesion.
DT 9602
AU Wakatsuki S; Yumoto N; Takagi T; Kurosu K; Sakai C; Tamayama C; Komatsu
T; Matsuzaki O; Mikata A; Division of Surgical Pathology, Chiba Cancer
Center Hospital,; Japan.
SO Pathol Int. 1995 Jun;45(6):457-62. Unique Identifier : AIDSLINE
MED/96086452
AB A case of T cell-rich B cell lymphoma (TCRBCL) with Epstein-Barr virus
(EBV) infection in tumor cells is reported. A 50 year old male developed
right cervical lymph node swelling in July 1988. Initial biopsy in April
1989 demonstrated many scattered Hodgkinoid atypical cells with
Lennert's lesion. After partial remission following chemotherapy, the
lymph nodes enlarged again, and a second biopsy in February 1991 showed
an IBL-T-like lesion. Only a small number of Hodgkinoid atypical cells
were still observed. After apparently, complete remission, the lesion
soon recurred and the patient died in November 1992.
Immunohistochemically the Hodgkinoid cells were positive for L26, but
negative for LN2, LN3, UCHL-1, MT1, lysozyme, Ber-H2 and Leu-M1.
Reactivity for immunoglobulins showed false-positive because of
polyclonal staining. IgH monoclonality was detected by the polymerase
chain reaction method in the first biopsied specimen, and by Southern
blotting in the second biopsied snap-frozen specimen. Monoclonal TCR
beta rearrangement was not detected. The Hodgkinoid atypical cells were
positive for EBV-encoding RNA by in situ hybridization, and LMP-1 by
immunostaining. Occasionally, EBV-bearing immunoblastic, medium sized,
or small lymphocytic cells were also observed. This case indicates the
possibility that EBV is related to the pathogenesis of TCRBCL.
DE Blotting, Southern Case Report *Herpesvirus 4, Human/GENETICS Human
Immunoblastic Lymphadenopathy/*PATHOLOGY/VIROLOGY In Situ Hybridization
Lymphoma, B-Cell/*PATHOLOGY/VIROLOGY Male Middle Age Polymerase Chain
Reaction RNA, Viral/ANALYSIS Tumor Virus
Infections/*PATHOLOGY/VIROLOGY Viral Matrix Proteins/ANALYSIS JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).