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M9620904.TXT
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1996-02-26
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Document 0904
DOCN M9620904
TI Evidence for an antiviral effect and interferon neutralizing capacity in
human sera; variability and implications for HIV infection.
DT 9602
AU Fall LS; Chams V; Le Coq H; Fouchard M; M'Bika JP; Gringeri A;
Santagostino E; Bizzini B; Laboratoire de Physiologie Cellulaire,
Universite Pierre et; Marie Curie, Paris, France.
SO Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):409-16. Unique Identifier
: AIDSLINE MED/96059402
AB The antiviral effect (AVE) and interferon neutralizing capacity (INC) of
sera originating from either seronegative or HIV-infected individuals
were determined. As a rule, sera from seropositive subjects exhibited
higher AVE titers than sera from seronegative individuals. Similarly,
the INC of sera from HIV-infected patients, was most often stronger than
that of sera from seronegative individuals. Furthermore, sera from
HIV-infected patients actively immunized with i-IFN alpha invariably
expressed INC in response to treatment, which was not the case for sera
from control unimmunized patients. All sera from HIV-infected patients
were found by ELISA to contain antibodies specifically directed to IFN
alpha.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/VIROLOGY Antibodies,
Viral/*IMMUNOLOGY Antibody Formation Antiviral Agents/BLOOD
Comparative Study CD4 Lymphocyte Count Enzyme-Linked Immunosorbent
Assay Female Human Immune Sera/*IMMUNOLOGY
Interferon-alpha/BLOOD/*IMMUNOLOGY Male Neutralization Tests Time
Factors Vaccination Vaccines, Synthetic/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).