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1996-02-26
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Document 0910
DOCN M9620910
TI Internal transcriptional regulatory elements in HIV-1 and other
retroviruses.
DT 9602
AU Verdin E; Van Lint C; Picower Institute for Medical Research, Laboratory
of Molecular; Virology, Manhasset, NY 11030, USA.
SO Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):365-9. Unique Identifier
: AIDSLINE MED/96059396
AB The transcriptional regulation of retroviruses plays an important role
in their pathogenesis. Cis-acting elements have been identified in the
long terminal repeat (LTR) at the 5' extremity of the integrated
provirus. These elements determine the rate and the site of
transcription initiation and consist of arrays of binding sites for
transcription factors. Recent studies have demonstrated the presence of
additional regulatory elements, located outside of the LTR, within the
transcribed region of several retroviruses including avian and murine
retroviruses, HIV-1, HTLV-1 and the human spumaretroviruses. This review
describes these new observations and analyzes their significance both in
terms of retroviral transcriptional regulation and in terms of
pathogenesis.
DE Animal *Gene Expression Regulation, Viral *Genes, Regulator Genome,
Viral Human HIV-1/*GENETICS/PATHOGENICITY HTLV-I/GENETICS Leukemia
Virus, Bovine/GENETICS Leukemia Viruses, Murine/GENETICS Mice
Promoter Regions (Genetics) Repetitive Sequences, Nucleic Acid
Retroviridae/*GENETICS/PATHOGENICITY Retroviruses, ALV-Related/GENETICS
Spumavirus/GENETICS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).