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1996-02-26
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Document 0911
DOCN M9620911
TI Kaposi's sarcoma in patients infected with human virus (HIV): an
overview.
DT 9602
AU Hermans P; Clumeck N; Division of Infectious Diseases, St. Pierre
University Hospital,; Brussels, Belgium.
SO Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):357-64. Unique Identifier
: AIDSLINE MED/96059395
AB The emergence of Kaposi's sarcoma (KS) among patients with HIV infection
has raised a number of unsolved questions. The particular epidemiology
and the etiology of KS remain unclear while both inflammatory cytokines
and HIV-derived proteins appear to be involved in its pathogenesis as
shown with the aid of in vitro KS-like cell cultures of animal models.
Since KS rarely occurs among HIV-positive Caucasian females, sexual
hormones, especially beta Human Chorionic Gonadotropin, have recently
been reported as providing theoretically some protection against KS both
in vitro and in vivo. All these aspects will be detailed as well as the
therapeutic approaches which still remain unsatisfactory. So far, there
is no curative treatment for KS and drug-induced toxicity is the
limiting factor for the prolonged use of the current approaches.
Perspectives for therapy will be discussed.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/EPIDEMIOLOGY
Cytokines/ADVERSE EFFECTS Cytomegalovirus Infections/COMPLICATIONS
Female Human Incidence Interferons/PHARMACOLOGY Male Sarcoma,
Kaposi's/*COMPLICATIONS/DRUG THERAPY/EPIDEMIOLOGY JOURNAL ARTICLE
REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).