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M9620923.TXT
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1996-02-26
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Document 0923
DOCN M9620923
TI Decreasing HIV-1 seroprevalence in young adults in a rural Ugandan
cohort.
DT 9602
AU Mulder D; Nunn A; Kamali A; Kengeya-Kayondo J; Medical Research Council
Programme on AIDS in Uganda, Entebbe.
SO BMJ. 1995 Sep 30;311(7009):833-6. Unique Identifier : AIDSLINE
MED/96066563
AB OBJECTIVE--To assess the trend in HIV-1 seroprevalence in an adult
population in Uganda. DESIGN--An observational cohort study with four
year follow up. SETTING--A cluster of 15 villages in rural Uganda.
SUBJECTS--All residents of the 15 villages--about 10,000 people. MAIN
OUTCOME MEASURE--Prevalence of HIV-1 infection as assessed by enzyme
immunoassay. RESULTS--During the five year period the overall
standardised seroprevalence of HIV-1 showed little change; 8.2% in 1990,
7.6% in 1994. Among males aged 13-24 years the prevalence decreased from
3.4% to 1.0% (P for trend < 0.001); among females of the same age the
corresponding values were 9.9% and 7.3%. The decrease was greatest in
males aged 20-24 years and females aged 13-19 years. CONCLUSION--This is
the first report of a decline in HIV-1 prevalence among young adults in
a general population in sub-Saharan Africa with high overall HIV-1
prevalence. It is too early to conclude that the epidemic in this
population is in decline, but the results of this study should be reason
for some cautious optimism and encourage the vigorous pursuit of AIDS
control measures.
DE Adolescence Adult Cohort Studies Female Follow-Up Studies Human
HIV Infections/*EPIDEMIOLOGY HIV Seroprevalence/TRENDS *HIV-1 Male
Prevalence *Rural Health Sex Factors Support, Non-U.S. Gov't
Uganda/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).