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M9620958.TXT
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1996-02-26
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Document 0958
DOCN M9620958
TI Clinical and host differences between infections with the two varieties
of Cryptococcus neoformans.
DT 9602
AU Speed B; Dunt D; Fairfield Hospital for Infectious Diseases, Victoria,
Australia.
SO Clin Infect Dis. 1995 Jul;21(1):28-34; discussion 35-6. Unique
Identifier : AIDSLINE MED/96065608
AB A population-based register of cases of cryptococcosis in patients
treated in Victoria, Australia, over a 10-year period was established
for studying the epidemiologic and clinical features of infection with
Cryptococcus neoformans and its two varieties, gattii and neoformans.
One hundred thirty-three cases of cryptococcosis were entered on the
register; the incidence was 3.0 cases per 1 million population per year,
a rate that increased to 5.0 cases per 1 million population per year
over the decade as a result of the AIDS epidemic. There was a distinct
association between immune status and C. neoformans variety: all C.
neoformans variety gattii infections occurred in healthy hosts and 90%
of C. neoformans variety neoformans infections occurred in
immunosuppressed hosts. Meningitis was the commonest manifestation, with
focal CNS and pulmonary lesions occurring primarily in healthy hosts
with C. neoformans variety gattii infection; isolation of C. neoformans
from blood and urine was associated with immunosuppression and C.
neoformans variety neoformans infection. The mortality among patients
with C. neoformans variety neoformans infection was high, while none of
those patients with C. neoformans variety gattii died but often had
neurological sequelae that required surgery and prolonged therapy. These
findings appear to be related to variety-specific interactions between
host and parasite and warrant further epidemiologic and immunologic
study.
DE Adolescence Adult Aged Aged, 80 and over Bacterial Typing Techniques
Brain/MICROBIOLOGY Cryptococcosis/*EPIDEMIOLOGY/IMMUNOLOGY/MICROBIOLOGY
Cryptococcus neoformans/*CLASSIFICATION/ISOLATION & PURIF Female Human
*Immunocompromised Host/IMMUNOLOGY Incidence Lung/MICROBIOLOGY Lung
Diseases, Fungal/MICROBIOLOGY Male Meningitis,
Cryptococcal/MICROBIOLOGY Middle Age Phenotype Registries
Victoria/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).