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1996-02-26
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Document 0957
DOCN M9620957
TI Multiorgan microsporidiosis: report of five cases and review.
DT 9602
AU Gunnarsson G; Hurlbut D; DeGirolami PC; Federman M; Wanke C; Department
of Medicine, New England Deaconess Hospital, Harvard; Medical School,
Boston, Massachusetts, USA.
SO Clin Infect Dis. 1995 Jul;21(1):37-44. Unique Identifier : AIDSLINE
MED/96065609
AB We describe five cases and review 34 reported cases of multiorgan
microsporidiosis. Most of the patients with multiorgan involvement have
been adults with AIDS. Organs most commonly infected include the small
intestine, urinary tract, biliary tree, and eye; involvement of the
respiratory tract, nasal sinuses, and central nervous system is also
described but appears to be less frequent. Although patients with
multiorgan disease may be asymptomatic, clinical presentation usually
relates to the involved organs. Enterocytozoon bieneusi and Septata
intestinalis are the most frequently identified species of pathogens. An
affinity for certain tissues is observed among different microsporidial
species. In all but one case of E. bieneusi infection, infection was
limited to intestinal and hepatobiliary tracts, a finding suggestive of
local extension. In contrast, the patients infected with S. intestinalis
had widespread involvement, suggesting true hematogenous or lymphatic
dissemination. Treatment may have to be based on findings regarding
which organs and specific microsporidial species are involved. Further
investigation of the pathogenic tendencies and route of acquisition of
these organisms and the therapeutic agents active against them is
needed.
DE Adult Albendazole/THERAPEUTIC USE Animal Anthelmintics/THERAPEUTIC
USE AIDS-Related Opportunistic Infections/DRUG THERAPY/PATHOLOGY/
*PARASITOLOGY Biliary Tract Diseases/DRUG
THERAPY/PATHOLOGY/PARASITOLOGY Brain Diseases/DRUG
THERAPY/PATHOLOGY/PARASITOLOGY Case Report Diarrhea/DRUG
THERAPY/PATHOLOGY/PARASITOLOGY Encephalitozoon/DRUG EFFECTS/ISOLATION &
PURIF Eye Infections, Parasitic/DRUG THERAPY/PATHOLOGY
Feces/PARASITOLOGY Human Intestinal Diseases, Parasitic/DRUG
THERAPY/PATHOLOGY Lung Diseases, Parasitic/DRUG THERAPY/PATHOLOGY
Macrophages/PARASITOLOGY Male Microspora Infections/DRUG
THERAPY/PATHOLOGY/*PARASITOLOGY Microsporida/DRUG EFFECTS/ISOLATION &
PURIF Middle Age Paranasal Sinus Diseases/DRUG
THERAPY/PATHOLOGY/PARASITOLOGY Urinary Tract Infections/DRUG
THERAPY/PATHOLOGY/PARASITOLOGY Urine/PARASITOLOGY JOURNAL ARTICLE
REVIEW REVIEW OF REPORTED CASES
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).