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M9620956.TXT
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1996-02-26
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Document 0956
DOCN M9620956
TI Disseminated microsporidiosis due to Septata intestinalis in nine
patients infected with the human immunodeficiency virus: response to
therapy with albendazole.
DT 9602
AU Dore GJ; Marriott DJ; Hing MC; Harkness JL; Field AS; Department of
Microbiology, St. Vincent's Hospital, Sydney,; Australia.
SO Clin Infect Dis. 1995 Jul;21(1):70-6. Unique Identifier : AIDSLINE
MED/96065615
AB Disseminated microsporidiosis due to the newly described species Septata
intestinalis in nine patients infected with human immunodeficiency virus
is described. All patients were male homosexuals; the mean age was 41
years (range, 35-58 years). They were all severely immunocompromised,
with a mean CD4 lymphocyte count of 15/mm3 (range, 0-32/mm3). Infection
by S. intestinalis was seen in duodenal biopsy specimens from all
patients, and dissemination was demonstrated by the presence of
microsporidial spores in urine (9 of 9 patients), sinonasal secretions
and/or nasal mucosal biopsy specimens (6 of 6), and sputum (6 of 6).
Seven patients were treated with albendazole (400 mg twice daily),
resulting in significant dissipation or complete resolution of diarrhea
for six patients and abatement of symptoms for the six patients with
chronic rhinosinusitis. There was a parallel parasitological response,
with clearance of S. intestinalis infection from almost all sites.
DE Adult Albendazole/*THERAPEUTIC USE Animal Anthelmintics/*THERAPEUTIC
USE AIDS-Related Opportunistic Infections/DRUG THERAPY/*PARASITOLOGY
Duodenum/PARASITOLOGY/ULTRASTRUCTURE Feces/PARASITOLOGY Human
Immunocompromised Host Intestinal Diseases, Parasitic/DRUG
THERAPY/*PATHOLOGY Male Microspora Infections/DRUG THERAPY/*PATHOLOGY
Microsporida/DRUG EFFECTS/*ISOLATION & PURIF/ULTRASTRUCTURE Middle Age
Nasal Lavage Fluid/PARASITOLOGY Sputum/PARASITOLOGY Urine/PARASITOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).