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1996-02-26
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Document 0955
DOCN M9620955
TI Clinical manifestations and implications of coinfection with
Mycobacterium kansasii and human immunodeficiency virus type 1.
DT 9602
AU Witzig RS; Fazal BA; Mera RM; Mushatt DM; Dejace PM; Greer DL; Hyslop NE
Jr; Department of Medicine, Tulane University School of Medicine, New;
Orleans, Louisiana 70112, USA.
SO Clin Infect Dis. 1995 Jul;21(1):77-85. Unique Identifier : AIDSLINE
MED/96065616
AB We conducted a retrospective study to further elucidate the clinical
presentations and prognosis of disease due to Mycobacterium kansasii in
patients infected with human immunodeficiency virus (HIV). Forty-nine
HIV-infected patients first had M. kansasii isolated at a mean CD4 cell
count of 62/mm3 and at a mean interval of 17 months after the diagnosis
of AIDS. Seventeen of the 49 patients had disseminated disease caused by
M. kansasii. Twenty-nine patients had a positive acid-fast smear of
sputum, and 35 were known to be cigarette smokers. At the time of
initial isolation of M. kansasii, 13 patients had other concurrent
pulmonary isolates and 15 had another mycobacterial species concurrently
isolated (the Mycobacterium avium complex in 13 instances). Patients who
received antimycobacterial treatment survived longer than those who did
not. Only one of the 49 patients was definitively determined to be
colonized with M. kansasii without disease; therefore, it appears that
pulmonary isolates of M. kansasii in HIV-infected patients are almost
always associated with disease. The increase in rates of M. kansasii
disease among HIV-infected patients has paralleled the rise of AIDS in
Louisiana. So far, this state has recorded more coinfections with M.
kansasii and HIV than any other.
DE Adolescence Adult Aged Aged, 80 and over Antibiotics/THERAPEUTIC USE
AIDS-Related Opportunistic Infections/*COMPLICATIONS/DIAGNOSIS/ DRUG
THERAPY CD4 Lymphocyte Count Female Human HIV
Infections/*COMPLICATIONS/DIAGNOSIS/DRUG THERAPY *HIV-1
Lung/MICROBIOLOGY Lung Diseases/MICROBIOLOGY Male Middle Age
Mycobacterium Infections, Atypical/*COMPLICATIONS/DIAGNOSIS/DRUG
THERAPY Mycobacterium, Atypical/*ISOLATION & PURIF Prognosis
Retrospective Studies Sputum/MICROBIOLOGY JOURNAL ARTICLE REVIEW
REVIEW OF REPORTED CASES
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).