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1996-02-26
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Document 1000
DOCN M9621000
TI Inducible nitric oxide synthase in the central nervous system.
DT 9602
AU Sparrow JR; Department of Ophthalmology, Cornell University Medical
College,; New York, NY 10021, USA.
SO J Mol Neurosci. 1994-95;5(4):219-29. Unique Identifier : AIDSLINE
MED/96101969
AB There is an accumulation of evidence indicating that induction of the
calcium-independent isoform of nitric oxide synthase (iNOS) in glial
cells can contribute to nitric oxide-mediated neural-cell damage.
Elucidation of iNOS inducing signals and mechanisms regulating its
augmentation and suppression may have implications for our understanding
of basic processes underlying some forms of central nervous system
disease.
DE Animal Astrocytes/ENZYMOLOGY AIDS Dementia
Complex/ENZYMOLOGY/PATHOLOGY Brain Diseases/ENZYMOLOGY/PATHOLOGY Cell
Death Central Nervous System/*ENZYMOLOGY
Encephalitis/ENZYMOLOGY/PATHOLOGY Enzyme Induction Human
Isoenzymes/BIOSYNTHESIS/PHYSIOLOGY Mice Nerve Tissue
Proteins/BIOSYNTHESIS/*PHYSIOLOGY Neuroglia/ENZYMOLOGY
Neurons/PATHOLOGY Nitric Oxide/METABOLISM Nitric-Oxide
Synthase/BIOSYNTHESIS/*PHYSIOLOGY Rats JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).