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1996-02-26
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Document 1067
DOCN M9621067
TI Micronutrient levels in HIV-1-infected children.
DT 9602
AU Periquet BA; Jammes NM; Lambert WE; Tricoire J; Moussa MM; Garcia J;
Ghisolfi J; Thouvenot J; Purpan Hospital, Toulouse, France.
SO AIDS. 1995 Aug;9(8):887-93. Unique Identifier : AIDSLINE MED/96014962
AB OBJECTIVE: Micronutrients (zinc, copper, selenium, vitamin A, E, and
carotenoids) are essential for the integrity of host defences. This
study was designed to determine the prevalence of abnormalities of the
micronutrient levels in HIV-1-seropositive children. DESIGN: Prospective
study. SETTING: The study was performed on HIV-1-infected children at
the Paediatric Haematology and Oncology Unit of Toulouse Hospital,
France. PATIENTS: Twenty-one children, suffering from HIV-1 infection
and 21 control subjects of similar age (2-9 years) were included in the
study. In the HIV-1-infected children, two subgroups were considered
according to stage (non-AIDS or AIDS), based on the Centers for Disease
Control and Prevention 1987 criteria. RESULTS: The first statistically
significant deficiencies occurred at non-AIDS stage and were confirmed
at AIDS stage: P < 0.05 for lycopene, retinol, tocopherol and P < 0.001
for transthyretin and serum albumin. Levels of copper (40%) and
long-chain polyunsaturated fatty acids (21%) were higher in the non-AIDS
group than the controls. CONCLUSION: Biological impairing of the
micronutrient levels was observed in the non-AIDS stage without clinical
sign. This information is useful in delineating eventual and well
considered nutritional intervention strategies that may improve the
clinical status of HIV-1-infected children and perhaps alter the course
of their disease.
DE Carotene/BLOOD/DEFICIENCY Case-Control Studies Child Child, Preschool
Copper/BLOOD Erythrocytes/METABOLISM Fatty Acids, Unsaturated/BLOOD
Female Human HIV Infections/*BLOOD/CLASSIFICATION/COMPLICATIONS
*HIV-1 Male Micronutrients/*METABOLISM Nutritional Status
Prealbumin/DEFICIENCY/METABOLISM Prospective Studies Serum
Albumin/DEFICIENCY Support, Non-U.S. Gov't Vitamin A/BLOOD Vitamin A
Deficiency/BLOOD/COMPLICATIONS Vitamin E/BLOOD Vitamin E
Deficiency/BLOOD/COMPLICATIONS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).