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1996-02-26
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Document 1068
DOCN M9621068
TI Campylobacter infections in HIV-infected patients: clinical and
bacteriological features.
DT 9602
AU Molina J; Casin I; Hausfater P; Giretti E; Welker Y; Decazes J; Garrait
V; Lagrange P; Modai J; Infectious Disease Department, Saint-Louis
Hospital, Paris,; France.
SO AIDS. 1995 Aug;9(8):881-5. Unique Identifier : AIDSLINE MED/96014961
AB OBJECTIVE: To study the clinical and bacteriological features of
Campylobacter infections in HIV-infected patients. DESIGN: A
retrospective analysis (1989-1992), followed by a prospective analysis
(1992-1994). SETTING: Hospital HIV inpatient unit. PATIENTS AND METHODS:
All patients with Campylobacter spp. identified by the laboratory of
microbiology at Saint-Louis Hospital, Paris were studied, and their
clinical features as well as their response to therapy recorded.
RESULTS: During the study period, Campylobacter infection was documented
in 38 HIV-infected patients, 76% of whom had AIDS. Campylobacter spp.
was isolated from stools in 36 cases and from blood cultures in four
cases. Species identification yielded C. jejuni (84%) and C. coli (16%).
High-level resistance to quinolones was frequently observed (21%), but
resistance to erythromycin (3%) and tetracycline (5%) was rare.
Diarrhoea, fever and abdominal pain were the main clinical features of
infection. Other intestinal pathogens were found in 42% of patients.
Most patients had an acute illness with rapid resolution under
appropriate antimicrobial therapy. However, eight patients (21%),
experienced chronic diarrhoea with persistent isolation of Campylobacter
and in vivo selection of resistant strains, requiring multiple courses
of antibiotics. CONCLUSIONS: Campylobacter usually cause acute diarrhoea
in patients with HIV infection. Antimicrobial therapy should be guided
on in vitro susceptibility testing because of the prevalence of
antibiotic resistance. Despite appropriate therapy, some patients will
present with prolonged diarrhoea and in vivo selection of multiresistant
isolates.
DE Adult Antibiotics/THERAPEUTIC USE AIDS-Related Opportunistic
Infections/*DIAGNOSIS/DRUG THERAPY/ MICROBIOLOGY *Campylobacter
coli/DRUG EFFECTS/ISOLATION & PURIF *Campylobacter jejuni/DRUG
EFFECTS/ISOLATION & PURIF Case Report Diarrhea/COMPLICATIONS/DRUG
THERAPY/MICROBIOLOGY Drug Resistance, Microbial Feces/VIROLOGY Female
Human Male Middle Age Prospective Studies Retrospective Studies
Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).