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- Document 1069
- DOCN M9621069
- TI Diagnosis and prognosis of AIDS-related cholangitis.
- DT 9602
- AU Ducreux M; Buffet C; Lamy P; Beaugerie L; Fritsch J; Choury A; Liguory
- C; Longuet P; Gendre JP; Vachon F; et al; Department of
- Hepato-Gastroenterology, Bicetre Hospital, Le; Kremlin Bicetre, France.
- SO AIDS. 1995 Aug;9(8):875-80. Unique Identifier : AIDSLINE MED/96014960
- AB OBJECTIVE: To determine more precisely the clinical and biological
- characteristics of AIDS-related cholangitis, and to investigate
- prognostic variables of this disease. DESIGN: Retrospective clinical and
- prognostic study. SETTING: Biliary unit, Bicetre Hospital, France.
- PATIENTS: HIV-positive patients (n = 52) referred to the unit between
- December 1986 and June 1993 for biliary symptoms leading to the
- suspicion of AIDS-related cholangitis, (42 men; 10 women; mean age, 37
- +/- 8 years). INTERVENTION: Endoscopic retrograde
- cholangiopancreatography (ERCP) was performed in order to determine the
- cause of the biliary symptoms. MAIN OUTCOME MEASURE: Clinical features
- and evolution of the cholangitis. RESULTS: Among the 52 patients, 45 met
- the ERCP criteria of AIDS-related cholangitis (36 men; nine women). The
- diagnosis of cholangitis was strongly suggested by abdominal
- ultrasonography in 47% of the cases. ERCP showed papillary stenosis,
- diffuse cholangitis, extrahepatic cholangitis alone, and intrahepatic
- cholangitis alone in 60, 67, 7 and 27%, respectively. Endoscopic
- sphincterotomy was performed in 28 patients. Pain was relieved by
- sphincterotomy in nine patients, but the other clinical or biological
- features were not influenced. One-year and 2-year survival rates were 41
- +/- 7% and 8 +/- 4%, respectively. Multidimensional analysis using a Cox
- model showed that a lymphocyte count > 500 x 10(6)/l was the only
- independent predictive factor of better survival. CONCLUSION:
- AIDS-related cholangitis is a disease which leads preferentially to
- papillary stenosis or diffuse abnormalities of the biliary tract.
- Prognostic factors depend on the stage of the HIV infection. Another
- diagnosis of cholestasis was found in approximately 15% of the patients
- who showed biliary symptoms.
- DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Alanine
- Aminotransferase/BLOOD Alkaline Phosphatase/BLOOD Bilirubin/BLOOD
- Cholangiopancreatography, Endoscopic Retrograde
- Cholangitis/*COMPLICATIONS/*DIAGNOSIS/SURGERY Female Human Lymphocyte
- Count Male Middle Age Prognosis Retrospective Studies
- Sphincterotomy, Endoscopic JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-