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1996-03-30
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Document 0942
DOCN M9650942
TI [A factor to enhance HIV replication in serum bearing a resemblance to
membranes of Acholeplasma laidlawii]
DT 9505
AU Hayashi R; Department of Bacteriology, Obstetrics & Gynecology, Kurume;
University School of Medicine.
SO Kansenshogaku Zasshi. 1995 Dec;69(12):1389-95. Unique Identifier :
AIDSLINE MED/96155225
AB We found a substance A in human serum by ELISA method, using anti-A
antibody. The substance A was obtained from the membranes of A.
laidlawii and this enhanced HIV replication. This substance in human
serum was detected in the chloroform phase of the Bligh-Dyer method. Rf
value in thin layer chromatography was 0.28. This substance clearly
showed enhancement of HIV replication as well as the activity of the
membranes of A. laidlawii, but did not induce TNF production.
Furthermore, the activity which enhances HIV replication in human serum
was reduced by anti-A antibody. These results suggest that the substance
derives from human serum which possesses a similar active site as those
of substance derived from the membrane of A. laidlawii.
DE *Acholeplasma laidlawii Bacterial Outer Membrane Proteins/*PHARMACOLOGY
English Abstract Enzyme-Linked Immunosorbent Assay Human
HIV/*PHYSIOLOGY Immune Sera/IMMUNOLOGY Virus Replication/*DRUG EFFECTS
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).