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1996-01-30
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Document 0546
DOCN M9610546
TI Chancroid and Haemophilus ducreyi: an update.
DT 9601
AU Trees DL; Morse SA; Division of Sexually Transmitted Disease, Centers
for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.
SO Clin Microbiol Rev. 1995 Jul;8(3):357-75. Unique Identifier : AIDSLINE
MED/96009213
AB Haemophilus ducreyi is a fastidious gram-negative bacillus that causes
the sexually transmitted infection chancroid. Chancroid is a major
genital ulcerative disease in Africa, Southeast Asia, the Caribbean, and
Latin America and is of increasing concern in the United States. Genital
ulcerative disease and chancroid in particular have been associated with
facilitating the transmission of human immunodeficiency virus. The
diagnosis of chancroid based on the clinical appearance of the genital
lesion or on the isolation of H. ducreyi on selective medium is
relatively insensitive. However, recent advances in nonculture
diagnostic tests have enhanced our ability to diagnose chancroid. There
has been renewed interest in understanding the pathogenesis of H.
ducreyi. In vitro and in vivo models have been developed to help
identify important virulence determinants. Through the use of
biochemical and molecular techniques, macromolecular components that may
be important in virulence have been identified.
DE Animal Antibody Formation Bacterial Typing Techniques
Chancroid/*DIAGNOSIS/DRUG THERAPY/EPIDEMIOLOGY/*MICROBIOLOGY Culture
Media/CHEMISTRY Forecasting Haemophilus ducreyi/*CLASSIFICATION/DRUG
EFFECTS/GROWTH & DEVELOPMENT/*PATHOGENICITY Human Microbial
Sensitivity Tests Virulence JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).