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1996-02-26
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Document 0215
DOCN M9620215
TI Toxoplasmosis and primary central nervous system lymphoma in HIV
infection: diagnosis with MR spectroscopy.
DT 9602
AU Chinn RJ; Wilkinson ID; Hall-Craggs MA; Paley MN; Miller RF; Kendall BE;
Newman SP; Harrison MJ; Department of Radiology, Middlesex Hospital,
University College; London Hospitals Trust, England.
SO Radiology. 1995 Dec;197(3):649-54. Unique Identifier : AIDSLINE
MED/96072845
AB PURPOSE: To differentiate intracranial lymphoma from Toxoplasma gondii
lesions in patients infected with the human immunodeficiency virus, by
means of localized spin-echo proton magnetic resonance (MR)
spectroscopy. MATERIALS AND METHODS: Twenty-seven lesions were studied
(18 T gondii lesions, nine lymphoma lesions) at 1.5 T. Spectra were
acquired at an echo time of 135 msec from voxels centered on the
lesions. Both visual analysis and spectral fitting were used to obtain
metabolite ratios for choline (Cho), creatine (Cr), N-acetyl (NA),
lactate, and lipids. RESULTS: Three spectral categories were seen. One
had large lipid peaks with suppression of other metabolites. Another had
an elevated Cho/Cr ratio with relatively diminished NA. The third had
features of the other two. Examples of each spectrum type were acquired
from both T gondii and lymphoma lesions. Neither method of analysis
allowed differentiation between lesion types. MR spectroscopy showed an
overlap of spectra. CONCLUSION: The authors conclude that toxoplasmosis
and lymphoma cannot be differentiated with spin-echo proton MR
spectroscopy at 135 msec.
DE Adult Aspartic Acid/ANALOGS & DERIVATIVES/METABOLISM AIDS-Related
Opportunistic Infections/*DIAGNOSIS/METABOLISM Brain
Neoplasms/*DIAGNOSIS/METABOLISM Choline/METABOLISM Creatine/METABOLISM
Diagnosis, Differential Female Human Lactates/METABOLISM
Lipids/METABOLISM Lymphoma, AIDS-Related/*DIAGNOSIS/METABOLISM
Magnetic Resonance Imaging Male Middle Age Nuclear Magnetic
Resonance/*DIAGNOSTIC USE Protons Signal Processing, Computer-Assisted
Support, Non-U.S. Gov't Toxoplasmosis, Cerebral/*DIAGNOSIS/METABOLISM
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).