home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Collection of Education
/
collectionofeducationcarat1997.iso
/
HEALTH
/
MED9602.ZIP
/
M9620216.TXT
< prev
next >
Wrap
Text File
|
1996-02-26
|
3KB
|
44 lines
Document 0216
DOCN M9620216
TI Brain lesions in patients with AIDS: H-1 MR spectroscopy.
DT 9602
AU Chang L; Miller BL; McBride D; Cornford M; Oropilla G; Buchthal S;
Chiang F; Aronow H; Ernst T; Department of Neurology, Harbor-University
of California Los; Angeles Medical Center, University of California Los
Angeles; School of Medicine, Torrance 90509, USA.
SO Radiology. 1995 Nov;197(2):525-31. Unique Identifier : AIDSLINE
MED/96027971
AB PURPOSE: To evaluate the role of proton (hydrogen-1) magnetic resonance
(MR) spectroscopy in the differential diagnosis of focal brain lesions
in patients with acquired immunodeficiency syndrome (AIDS). MATERIALS
AND METHODS: Twenty-six men with 35 AIDS-related brain lesions underwent
MR imaging and localized H-1 MR spectroscopy. Lesions consisted of 11
toxoplasmic abscesses, 12 progressive multifocal leukoencephalopathic
lesions, eight lymphomas, and four cryptococcomas. Metabolite peak areas
in the lesions were compared with those in the contralateral hemisphere
in each patient. RESULTS: H-1 MR spectroscopic findings showed
significantly different biochemical profiles for each diagnostic group
(P = .0001) with regard to N-acetyl compounds, total creatine pool,
choline-containing compounds, myoinositol, and lactate. H-1 MR
spectroscopy alone helped correctly diagnose 94% (84% with jackknifed
classification) of the brain lesions, without overlap between
toxoplasmosis and lymphoma. CONCLUSION: H-1 MR spectroscopy is a
sensitive and potentially specific noninvasive adjunctive method for
differential diagnosis of focal brain lesions in AIDS.
DE Abscess/DIAGNOSIS/METABOLISM/PARASITOLOGY Adult Aspartic Acid/ANALOGS
& DERIVATIVES/METABOLISM AIDS Dementia
Complex/*DIAGNOSIS/METABOLISM/MICROBIOLOGY/ PARASITOLOGY Brain
Diseases/*DIAGNOSIS/METABOLISM/MICROBIOLOGY Brain
Neoplasms/DIAGNOSIS/METABOLISM Choline/METABOLISM Comparative Study
Creatine/METABOLISM Cryptococcosis/DIAGNOSIS/METABOLISM Diagnosis,
Differential Human Hydrogen Inositol/METABOLISM Lactates/METABOLISM
Leukoencephalopathy, Progressive Multifocal/DIAGNOSIS/METABOLISM
Lymphoma, AIDS-Related/DIAGNOSIS/METABOLISM Magnetic Resonance Imaging
Male Middle Age Nuclear Magnetic Resonance/*DIAGNOSTIC USE
Sensitivity and Specificity Support, U.S. Gov't, P.H.S. Toxoplasmosis,
Cerebral/DIAGNOSIS/METABOLISM JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).