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1996-02-26
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Document 0303
DOCN M9620303
TI Immune response to changes in training intensity and volume in runners.
DT 9602
AU Kajiura JS; MacDougall JD; Ernst PB; Younglai EV; Department of
Kinesiology, McMaster University, Hamilton,; Ontario, Canada.
SO Med Sci Sports Exerc. 1995 Aug;27(8):1111-7. Unique Identifier :
AIDSLINE MED/96021390
AB We examined the acute and chronic effects of changes in training volume
and intensity on the blood lymphocyte percentages and immunoglobulin
levels in runners. Twelve runners participated in four 10-d phases of
low volume/low intensity (LV/LI), high volume/low intensity (HV/LI), or
high volume/high intensity (HV/HI) running. Subjects were assigned to
one of two different training group orders: 1) LV/LI, HV/LI, LV/LI,
HV/HI; or 2) LV/LI, HV/HI, LV/LI, HV/LI. Venous blood was drawn at rest
on days 1, 4, and 7; and 5 min post-exercise on days 1 and 7 of each
10-d phase. Lymphocyte subsets were determined by flow cytometry for
CD3+, CD4+, CD8+, and HLA-DR+. IgG, and IgM levels were obtained by
ELISA analysis. Immunoglobulin, CD8+ and HLA-DR+ levels, and
pre-exercise plasma cortisol concentrations were not significantly
affected by alterations in volume or intensity. A transient decrease (P
< 0.05) was observed in CD4+ and the CD4/CD8 ratio 5 min post-exercise
during the HV/LI and HV/HI phases. Results indicate that the
exercise-induced lymphocyte subset reduction is transient and suggest
that it is more dependent upon training intensity than volume, and the
training order of exposure to the high-intensity stimulus may determine
the magnitude of subsequent responses.
DE Adolescence Adult CD4 Lymphocyte Count CD4-CD8 Ratio CD4-Positive
T-Lymphocytes/CYTOLOGY CD8-Positive T-Lymphocytes/CYTOLOGY Flow
Cytometry Human Hydrocortisone/BLOOD HLA-DR Antigens/ANALYSIS
IgA/BLOOD IgG/BLOOD IgM/BLOOD Immunoglobulins/*BLOOD Lymphocyte
Count Male Physical Education and Training Running/*PHYSIOLOGY
Support, Non-U.S. Gov't T-Lymphocyte Subsets/CYTOLOGY
T-Lymphocytes/*CYTOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).