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Document 0304
DOCN M9620304
TI In vivo effects of superantigens.
DT 9602
AU Blackman MA; Woodland DL; Department of Immunology, St. Jude Children's
Research Hospital,; Memphis, TN 38105, USA.
SO Life Sci. 1995 Sep 29;57(19):1717-35. Unique Identifier : AIDSLINE
MED/96068852
AB Superantigens are potent immunostimulatory molecules that activate both
T cells and antigen presenting cells. The consequences of superantigen
exposure range from induction of T cell proliferation, massive cytokine
release and systemic shock to immunosuppression and tolerance.
Superantigens have been directly implicated in a number of human
conditions including food poisoning and toxic shock. In addition, there
is evidence to suggest that superantigens are involved in the initiation
of autoimmunity, and the immune dysfunction associated with HIV
infection. Because of their possible role in human disease, and their
potential use in immune therapy, it is important that we more completely
understand the in vivo effects of superantigens.
DE Animal Human Immune Tolerance
Superantigens/*IMMUNOLOGY/*PHARMACOLOGY/TOXICITY Support, Non-U.S.
Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW,
TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).