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1996-02-26
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Document 0447
DOCN M9620447
TI [AIDS dementia. Prognosis and therapeutic perspectives]
DT 9602
AU Lubetzki C; Inserm U-134, Hopital de la Salpetriere, Paris.
SO J Neuroradiol. 1995 Sep;22(3):169-71. Unique Identifier : AIDSLINE
MED/96043311
AB AIDS dementia complex is a severe complication related to HIV infection
of the central nervous system. It has been estimated to affect about 7%
of AIDS patients, with an increased frequency in very young and old
patients. In most cases, it appears in severely immuno-deficient
patients. Typically, AIDS dementia presents as a subcortical dementia
with cognitive, behavioural and motor decline. The mechanism of the
dementia remains unclear; the neuronal loss is controversial and a
neurotoxicity due to NMDA receptor activation is likely. No treatment
proved to be efficient. Beneficial effect of anti-NMDA receptor
antagonists are under investigation.
DE Adult Age Factors AIDS Dementia Complex/DRUG
THERAPY/PHYSIOPATHOLOGY/*THERAPY English Abstract Human Middle Age
Neurons/PATHOLOGY Prognosis Receptors,
N-Methyl-D-Aspartate/ANTAGONISTS & INHIB/PHYSIOLOGY JOURNAL ARTICLE
REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).