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M9620488.TXT
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1996-02-26
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Document 0488
DOCN M9620488
TI High prevalence of human T cell lymphotropic virus type II infection in
patients affected by human immunodeficiency virus type 1--associated
predominantly sensory polyneuropathy.
DT 9602
AU Zehender G; De Maddalena C; Osio M; Cavalli B; Parravicini C; Moroni M;
Galli M; Clinica delle Malattie Infettive, University of Milan, Italy.
SO J Infect Dis. 1995 Dec;172(6):1595-8. Unique Identifier : AIDSLINE
MED/96083509
AB The etiopathogenesis of peripheral neuropathy (PN) that frequently
affects human immunodeficiency virus (HIV) type 1-positive patients
remains undefined. Forty-seven HIV-1-positive patients with PN (8 with
inflammatory demyelinating polyneuropathy and 39 with predominantly
sensory polyneuropathy [PSP]) and 266 controls with symptomatic HIV-1
infection without PN were screened for antibodies to human T cell
lymphotropic virus (HTLV) types I and II. The prevalence of antibodies
to HTLV-II was significantly higher in patients with PSP than in
controls (30.8% vs. 8.3%; P < .001). All seropositive patients with PN
had HTLV-II DNA in their peripheral blood mononuclear cells by
polymerase chain reaction (PCR) analysis. PCR analysis of tissues from 1
patient with PSP who died during the study showed HTLV-II proviral
sequences in the femoral nerve and basal nuclei. These results support
the hypothesis that HTLV-II represents an etiologic factor in the
pathogenesis of a considerable proportion of PSP in patients infected
with HIV-1.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult DNA,
Viral/ANALYSIS Female Human *HIV-1 HTLV-II Antibodies/BLOOD HTLV-II
Infections/*COMPLICATIONS/EPIDEMIOLOGY Male Peripheral Nervous System
Diseases/*ETIOLOGY Polymerase Chain Reaction Prevalence Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).