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1996-02-26
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Document 1014
DOCN M9621014
TI Defective natural killer cell cytotoxic activity in feline
immunodeficiency virus-infected cats.
DT 9602
AU Zaccaro L; Falcone ML; Silva S; Bigalli L; Cecchettini A; Giorgi F;
Malvaldi G; Bendinelli M; Centro Retrovirus, Universita di Pisa, Italy.
SO AIDS Res Hum Retroviruses. 1995 Jun;11(6):747-52. Unique Identifier :
AIDSLINE MED/96078236
AB Flow cytometry has been employed to study NK cell cytotoxic activity in
cats infected with feline immunodeficiency virus. The results show that
animals infected for 12 months or more have decreased levels of NK cell
cytotoxic activity in their blood. The impairment could not be overcome
by in vitro treatment of effector cells with interleukin 2. Additional
results suggest that the NK cells of infected cats are defective, in
that they are still able to bind to target cells but have a reduced
ability to kill them.
DE Animal Cats Cytotoxicity Tests, Immunologic/METHODS *Cytotoxicity,
Immunologic CD4-CD8 Ratio Immunodeficiency Virus, Feline/*IMMUNOLOGY
Interleukin-2/PHARMACOLOGY Killer Cells, Natural/*IMMUNOLOGY
Lentivirus Infections/*IMMUNOLOGY Leukocytes, Mononuclear/DRUG EFFECTS
Matched-Pair Analysis Specific Pathogen-Free Organisms Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).